Top-down and bottom-up modulation of language related areas - an fMRI study

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Paper (help)
Top-down and bottom-up modulation of language related areas - an fMRI study
Authors: Tömme Noesselt, Nadim Jon Shah, Lutz Jäncke
Citation: BMC Neuroscience 4 : 13. 2003
Database(s): PubMed (PMID/12828789)
DOI: 10.1186/1471-2202-4-13.
Link(s): http://www.biomedcentral.com/1471-2202/4/13
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Top-down and bottom-up modulation of language related areas - an fMRI study reports a functional magnetic resonance imaging study.

Contents

[edit] Abstract

Abtract from the Open Access article published under CC-BY:

[edit] Background

One major problem for cognitive neuroscience is to describe the interaction between stimulus and task driven neural modulation. We used fMRI to investigate this interaction in the human brain. Ten male subjects performed a passive listening and a semantic categorization task in a factorial design. In both tasks, words were presented auditorily at three different rates.

[edit] Results

We found: (i) as word presentation rate increased hemodynamic responses increased bilaterally in the superior temporal gyrus including Heschl's gyrus (HG), the planum temporale (PT), and the planum polare (PP); (ii) compared to passive listening, semantic categorization produced increased bilateral activations in the ventral inferior frontal gyrus (IFG) and middle frontal gyrus (MFG); (iii) hemodynamic responses in the left dorsal IFG increased linearly with increasing word presentation rate only during the semantic categorization task; (iv) in the semantic task hemodynamic responses decreased bilaterally in the insula with increasing word presentation rates; and (v) in parts of the HG the hemodynamic response increased with increasing word presentation rates during passive listening more strongly.

[edit] Conclusion

The observed "rate effect" in primary and secondary auditory cortex is in accord with previous findings and suggests that these areas are driven by low-level stimulus attributes. The bilateral effect of semantic categorization is also in accord with previous studies and emphasizes the role of these areas in semantic operations. The interaction between semantic categorization and word presentation in the left IFG indicates that this area has linguistic functions not present in the right IFG. Finally, we speculate that the interaction between semantic categorization and word presentation rates in HG and the insula might reflect an inhibition of the transfer of unnecessary information from the temporal to frontal regions of the brain.

[edit] Subjects

Subject group #1 (help)
Healthy
Subjects/♂/♀: 10 / 10 / 0
Age: (21–27)
Handedness: Right
Nationality: define nationality
Approval: define approval
Databases:

Group 1 of 10 right-handed healthy with 10 males and 0 females were included in the study. The group was from 21 up to 27 years old.


[edit] Scanning

MRI Scanning (help)
Mode: fMRI
Scanner: Siemens Magnetom Vision 1.5T
Type: gradient echo echo planar imaging

(TR=6000ms, TE=66ms, FA=90°)

Slices: 16 (thickness=3mm , gap=0.3mm) oriented Parallel to the AC-PC-line
Size: FOV=200x200mm matrix=64x64 resolution=3.125x3.125mm
Laboratory: missing laboratory

For fMRI gradient echo echo planar imaging scans were acquired with a 1.5T Siemens Magnetom Vision.

MRI Scanning (help)
Mode: aMRI
Scanner: Siemens Magnetom Vision 1.5T
Type: T1-weighted MP-RAGE

(TR=11.4ms, TE=4.4ms, FA=15°)

Slices: 128
Size: FOV=250mm matrix=256 x 256 resolution=0.98 x 0.98mm
Laboratory: missing laboratory

For aMRI T1-weighted MP-RAGE scans were acquired with a 1.5T Siemens Magnetom Vision.


[edit] Results

The neuroimages was normalized to "the template provided by the Montreal Neurological Institute" using SPM99.

[edit] Rate effect

Table 1 with 6 coordinates [1].

Anatomy
BA
x
y
z
No. vox
t
z
Coordinate search
Plot
1 Left Heschl's gyrus -64 -16 8 386 >10 Brede Database Brede Wiki NeuroSynth SumsDB Not available
1 Left planum polare -60 -4 4 7.7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
3 Left planum temporale -44 -28 12 7.6 Brede Database Brede Wiki NeuroSynth SumsDB Not available
4 Right planum polare 56 -8 -4 430 7.1 Brede Database Brede Wiki NeuroSynth SumsDB Not available
5 Right Heschl's gyrus 64 -20 12 7.0 Brede Database Brede Wiki NeuroSynth SumsDB Not available
6 Right planum temporale 56 -28 16 6.9 Brede Database Brede Wiki NeuroSynth SumsDB Not available
Entry not completed (help)

[edit] Semantic categorization effect

Table 2 with 8 coordinates [2].

Anatomy
BA
x
y
z
No. vox
t
z
Coordinate search
Plot
1 vIFG R 40 24 -8 224 6.5 Brede Database Brede Wiki NeuroSynth SumsDB Not available
2 ant. INS R 44 -4 8 2.4 Brede Database Brede Wiki NeuroSynth SumsDB Not available
3 MFG R 36 48 16 210 5.4 Brede Database Brede Wiki NeuroSynth SumsDB Not available
4 dIFG R 56 24 20 4.4 Brede Database Brede Wiki NeuroSynth SumsDB Not available
5 MFG R 32 60 16 3.7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
6 vIFG L -44 24 -4 270 5.4 Brede Database Brede Wiki NeuroSynth SumsDB Not available
7 vIFG L -32 32 -4 5.1 Brede Database Brede Wiki NeuroSynth SumsDB Not available
8 MFG L -48 52 -8 3.9 Brede Database Brede Wiki NeuroSynth SumsDB Not available
Entry not completed (help)
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