Serotonin receptor 3A (HTR3A) gene is associated with personality traits, but not panic disorder
|Serotonin receptor 3A (HTR3A) gene is associated with personality traits, but not panic disorder|
|Authors:||Naoki Mizuta, Jotaro Akiyoshi, Asami Sato, Hiroaki Hanada, Yoshihiro Tanaka, Jusen Tsuru, Hirotaka Matsushita, Kensuke Kodama, Koichi Isogawa|
|Citation:||Psychiatric Genetics 18 (1): 44. 2008 February|
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|Article:||BASE Google Scholar PubMed|
|Restricted:||DTU Digital Library|
|Format:||BibTeX Template from PMID|
Serotonin receptor 3A (HTR3A) gene is associated with personality traits, but not panic disorder reports a personality genetics study and an association study on panic disorder on the HTR3A gene and its C178T genetic polymorphism. Personality traits were assessed with Temperament and Character Inventory and NEO-FFI.
It is inspired by the study A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women.
|Subject group #1 (help)|
|Healthy Japanese university staff and students|
|Subjects/♂/♀:||122 / 75 / 47|
|Age:||23.2 ±13.4 (–)|
Group 1 of 122 healthy Japanese university staff and students with 75 males and 47 females were included in the study.The Japanese group had a mean age of 23.2.
|Subject group #2 (help)|
|Japanese Panic order patients|
|Subjects/♂/♀:||82 / 40 / 42|
|Age:||26.3 ±11.8 (–)|
Group 2 of 82 japanese Panic order patients with 40 males and 42 females were included in the study. The Japanese group had a mean age of 26.3.
No personality scores are given. It is stated that "the C/C genotype of C178T was associated with higher harm avoidance of Temperament and Character Inventory and Neuroticism (N) of NEO-FFI score than those with C/T genotype."
The difference in genotype distribution between panic disorder patients and controls were not significant.