Regional brain activity in women grieving a romantic relationship breakup

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Paper (help)
Regional brain activity in women grieving a romantic relationship breakup
Authors: Arif Najib, Jeffrey P. Lorberbaum, Samet Kose, Daryl E. Bohning, Mark S. George
Citation: American Journal of Psychiatry 161 (12): 2245-2256. 2004 December
Database(s): PubMed (PMID/15569896)
DOI: Define doi.
Link(s): http://ajp.psychiatryonline.org/cgi/reprint/161/12/2245.pdf
http://ajp.psychiatryonline.org/cgi/content/full/161/12/2245
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Format: BibTeX Template from PMID
Extract: Talairach coordinates from linked PDF: CSV-formated wiki-formated

Regional brain activity in women grieving a romantic relationship breakup reports a functional magnetic resonance imaging study on women grieving after a romantic love relationship breakup.

Subjects also completed the Hamilton Anxiety Rating Scale, the 28-item Hamilton Depression Rating Scale, Beck Depression Inventory, Clonings's Temperament and Character Inventory, a modified version of the Inventory of Complicated Grief and Positive and Negative Affect Schedule.

Contents

[edit] Scanning

MRI Scanning (help)
Mode: fMRI
Scanner: Picker EDGE 1.5T
Type: Asymmetric spin-echo echo-planar pulse

(TR=6000ms, TE=45ms, FA=?)

Slices: 18 oriented Axial
Size: FOV=300 x 300mm matrix=128 x 128 resolution=2.344 x 2.344mm
Laboratory: Medical University of South Carolina

For fMRI Asymmetric spin-echo echo-planar pulse scans were acquired with a 1.5T Picker EDGE at Medical University of South Carolina.


[edit] Results

Data analysis was performed wihth MEDx 3.3/SPM 96 with spatial normalization "into Talairach space".

A z score height on 1.654 was use together with a cluster corrected P-value threshold on <0.05 corresponding to 274 voxels. On regions of interest another threshold was used on cluster size 10 voxels.

[edit] Ruminative versus neutral thought

40 coordinates in Table 3 [1]
Experiment #1 : Ruminative versus neutral thought in grieving women (help)
Description: Ruminative thought as most frequent and intense sad thoughts in grieving women after a romantic breakup versus neutral thought about a different person known to the woman
Scanning:
Topic: Romantic love Grieving
Analysis:
Databases:

Anatomy
BA
x
y
z
No. vox
t
z
Coordinate search
Plot
1 Left cerebellum -9 -68 -28 2.08 Brede Database Brede Wiki NeuroSynth SumsDB Not available
2 0 -54 -21 Brede Database Brede Wiki NeuroSynth SumsDB Not available
3 -16 -59 -28 Brede Database Brede Wiki NeuroSynth SumsDB Not available
4 23 -82 -21 Brede Database Brede Wiki NeuroSynth SumsDB Not available
5 -7 -77 -21 Brede Database Brede Wiki NeuroSynth SumsDB Not available
6 5 -61 0 Brede Database Brede Wiki NeuroSynth SumsDB Not available
7 -12 -45 -14 Brede Database Brede Wiki NeuroSynth SumsDB Not available
8 -7 -75 -7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
9 Brainstem: posterior pons 2 -35 -28 Brede Database Brede Wiki NeuroSynth SumsDB Not available
10 Parahippocampal gyrus/hippocampus -16 -40 0 Brede Database Brede Wiki NeuroSynth SumsDB Not available
11 Superior/middle temporal gyrus 40 -52 21 Brede Database Brede Wiki NeuroSynth SumsDB Not available
12 Medial occipital gyrus/middle temporal gyrus 26 -70 28 Brede Database Brede Wiki NeuroSynth SumsDB Not available
13 52 -49 28 Brede Database Brede Wiki NeuroSynth SumsDB Not available
14 -23 -59 7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
15 35 -59 7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
16 -12 -56 14 Brede Database Brede Wiki NeuroSynth SumsDB Not available
17 -7 -45 21 Brede Database Brede Wiki NeuroSynth SumsDB Not available
18 -2 -61 21 Brede Database Brede Wiki NeuroSynth SumsDB Not available
19 16 -75 21 Brede Database Brede Wiki NeuroSynth SumsDB Not available
20 -19 -45 35 Brede Database Brede Wiki NeuroSynth SumsDB Not available
21 7 -37 42 Brede Database Brede Wiki NeuroSynth SumsDB Not available
22 -14 -63 35 Brede Database Brede Wiki NeuroSynth SumsDB Not available
23 -7 -73 35 Brede Database Brede Wiki NeuroSynth SumsDB Not available
24 12 -63 35 Brede Database Brede Wiki NeuroSynth SumsDB Not available
25 -21 -68 35 Brede Database Brede Wiki NeuroSynth SumsDB Not available
26 16 -80 35 Brede Database Brede Wiki NeuroSynth SumsDB Not available
27 0 -33 49 Brede Database Brede Wiki NeuroSynth SumsDB Not available
28 -28 -56 49 Brede Database Brede Wiki NeuroSynth SumsDB Not available
29 21 -59 49 Brede Database Brede Wiki NeuroSynth SumsDB Not available
30 -26 -91 0 Brede Database Brede Wiki NeuroSynth SumsDB Not available
31 26 -91 0 Brede Database Brede Wiki NeuroSynth SumsDB Not available
32 -9 -84 0 Brede Database Brede Wiki NeuroSynth SumsDB Not available
33 19 -68 0 Brede Database Brede Wiki NeuroSynth SumsDB Not available
34 -16 -87 7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
35 12 -84 7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
36 40 -70 -7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
37 -19 -80 14 Brede Database Brede Wiki NeuroSynth SumsDB Not available
38 19 -75 7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
39 28 -77 7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
40 37 -77 7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
Entry not completed (help)

[edit] Neutral versus ruminative thought

49 coordinates in Table 4 [2]
Experiment #2 : Neutral thought versus ruminative thought in grieving women (help)
Description: missing description
Scanning:
Topic:
Analysis:
Databases:

Anatomy
BA
x
y
z
No. vox
t
z
Coordinate search
Plot
1 Anterior pons -7 -14 -21 2.92 Brede Database Brede Wiki NeuroSynth SumsDB Not available
2 Midbrain/hypothalamus -9 -5 -7 3.32 Brede Database Brede Wiki NeuroSynth SumsDB Not available
3 Thalamus: lateral and medial thalamus -16 -14 14 2.32 Brede Database Brede Wiki NeuroSynth SumsDB Not available
4 Left ventral striatum/amygdala -16 12 -7 3.19 Brede Database Brede Wiki NeuroSynth SumsDB Not available
5 Right ventral striatum/amygdala 14 9 -7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
6 Left central striatum 21 14 -7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
7 -28 -5 -7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
8 -16 -9 -7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
9 -19 2 -21 Brede Database Brede Wiki NeuroSynth SumsDB Not available
10 -45 5 -28 Brede Database Brede Wiki NeuroSynth SumsDB Not available
11 -35 12 -28 Brede Database Brede Wiki NeuroSynth SumsDB Not available
12 -54 -9 -21 Brede Database Brede Wiki NeuroSynth SumsDB Not available
13 -45 -7 -7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -47 -19 0 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -28 19 0 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -21 21 14 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -26 12 14 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n 2 14 -14 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -19 30 7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n 5 49 -7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -26 42 7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n 7 42 -7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -9 61 0 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n 0 70 0 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -5 30 14 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -23 -9 21 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n 12 28 14 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -5 7 28 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n 12 16 -21 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -28 28 -14 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -33 40 0 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n 28 35 -7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n 5 56 -14 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n 19 30 -14 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n 21 49 -14 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -40 59 -7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -30 49 21 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -40 45 7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -45 21 7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -45 23 21 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -33 5 21 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -40 14 21 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -30 12 28 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -26 21 35 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n -49 7 35 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n 6 -49 5 7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n 6 -28 -7 35 Brede Database Brede Wiki NeuroSynth SumsDB Not available
missing n 6 -47 -7 42 Brede Database Brede Wiki NeuroSynth SumsDB Not available
49 Sensory cortex: sensory cortex/postcentral gyrus 43 -56 -12 21 3.17 Brede Database Brede Wiki NeuroSynth SumsDB Not available
Entry not completed (help)

[edit] Critique

  1. A varying statistical threshold was used across the brain.
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