Genome-wide association scan for five major dimensions of personality

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Genome-wide association scan for five major dimensions of personality
Authors: Antonio Terracciano, Serena Sanna, Manuela Uda, B. Deiana, G. Usala, F. Busonero, A. Maschio, M. Scally, N. Patriciu, W.-M. Chen, M. A. Distel, E. P. Slagboom, D. I. Boomsma, S. Villafuerte, E. S. Śliwerska, M. Burmeister, N. Amin, A. C. J. W. Janssens, C. M. van Duijn, D. Schlessinger , Gonçalo R. Abecasis, Paul T. Costa, Jr.
Citation: Molecular Psychiatry 15 (6): 647-656. 2010 June
Database(s): Google Scholar cites PubMed (PMID/18957941)
DOI: 10.1038/mp.2008.113.
Link(s): http://www.tweelingenregister.org/nederlands/verslaggeving/NTR-publicaties_2008/Terracciano_MP_2008epub.pdf
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Genome-wide association scan for five major dimensions of personality is as of 2008 one of the largest personality genetics studies and is a genome-wide association study investigating genetic variants relationship to NEO PI-R personality traits. The study examined 362129 single-nucleotide polymorphisms and 3972 individuals from Sardinia.

A related study are A genome-wide scan for Eysenckian personality dimensions in adolescent twin sibships: psychoticism, extraversion, neuroticism, and lie from 2008.

[edit] Subjects

Subject group #1 (help)
Sardinians
Subjects/♂/♀: 3972 / 1722 / 2250
Age: 42.8 ±17 (14–94)
Nationality: Italian
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Group 1 of 3972 sardinians with 1722 males and 2250 females were included in the study. The Italian group had a mean age of 42.8 with a range from 14 to 94.

6148 individuals were recruited originally.
Subject group #2 (help)
Tecumseh Americans
Subjects/♂/♀: 923 /  /
Age: 44.3 ±15.7 (–)
Nationality: American
Approval: define approval
Databases:

Group 2 of 923 tecumseh Americans were included in the study.

The American group had a mean age of 44.3.
Subject group #3 (help)
Dutch
Subjects/♂/♀: 1158 /  /
Age: 45.3 ±14.6 (–)
Nationality: Dutch
Approval: define approval
Databases:

Group 3 of 1158 dutch were included in the study. The Dutch group had a mean age of 45.3.

The American and Dutch group were replication samples and these did not have the full genome-wide genotyping. Instead only six top SNPs from an analysis of the first group were performed on the two latter groups.

[edit] Results

The association study points to the following connections:

  1. Neuroticism and SNAP25 rs362584
  2. Extraversion and BDNF
  3. Extraversion and CDH13
  4. Extraversion and CDH23
  5. Openness and CNTNAP2
  6. Agreeableness with CLOCK
  7. Conscientiousnes with DYRK1A

Effect sizes were small and except for CLOCK they failed to replicate.

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