Genome-wide association scan for five major dimensions of personality
|Genome-wide association scan for five major dimensions of personality|
|Authors:||Antonio Terracciano, Serena Sanna, Manuela Uda, B. Deiana, G. Usala, F. Busonero, A. Maschio, M. Scally, N. Patriciu, W.-M. Chen, M. A. Distel, E. P. Slagboom, D. I. Boomsma, S. Villafuerte, E. S. Śliwerska, M. Burmeister, N. Amin, A. C. J. W. Janssens, C. M. van Duijn, D. Schlessinger , Gonçalo R. Abecasis, Paul T. Costa, Jr.|
|Citation:||Molecular Psychiatry 15 (6): 647-656. 2010 June|
|Database(s):||Google Scholar cites PubMed (PMID/18957941)|
|Web:||Bing Google Yahoo! — Google PDF|
|Article:||BASE Google Scholar PubMed|
|Restricted:||DTU Digital Library|
|Format:||BibTeX Template from PMID|
|Extract:||Talairach coordinates from linked PDF: CSV-formated wiki-formated|
Genome-wide association scan for five major dimensions of personality is as of 2008 one of the largest personality genetics studies and is a genome-wide association study investigating genetic variants relationship to NEO PI-R personality traits. The study examined 362129 single-nucleotide polymorphisms and 3972 individuals from Sardinia.
|Subject group #1 (help)|
|Subjects/♂/♀:||3972 / 1722 / 2250|
|Age:||42.8 ±17 (14–94)|
Group 1 of 3972 sardinians with 1722 males and 2250 females were included in the study. The Italian group had a mean age of 42.8 with a range from 14 to 94.6148 individuals were recruited originally.
|Subject group #2 (help)|
|Subjects/♂/♀:||923 / /|
|Age:||44.3 ±15.7 (–)|
Group 2 of 923 tecumseh Americans were included in the study.The American group had a mean age of 44.3.
|Subject group #3 (help)|
|Subjects/♂/♀:||1158 / /|
|Age:||45.3 ±14.6 (–)|
Group 3 of 1158 dutch were included in the study. The Dutch group had a mean age of 45.3.
The American and Dutch group were replication samples and these did not have the full genome-wide genotyping. Instead only six top SNPs from an analysis of the first group were performed on the two latter groups.
The association study points to the following connections:
- Neuroticism and SNAP25 rs362584
- Extraversion and BDNF
- Extraversion and CDH13
- Extraversion and CDH23
- Openness and CNTNAP2
- Agreeableness with CLOCK
- Conscientiousnes with DYRK1A
Effect sizes were small and except for CLOCK they failed to replicate.