Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism

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Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism
Authors: Edwin J. van den Oord, Po-Hsiu Kuo, Annette M. Hartmann, B. Todd Webb, Hans-Jürgen Möller, John M. Hettema, Ina Giegling, József Bukszár, Dan Rujescu
Citation: Archives of General Psychiatry 65 (9): 1062-1071. 2008 September
Database(s): PubMed (PMID/18762592)
DOI: 10.1001/archpsyc.65.9.1062.
Link(s): http://www.psych.umn.edu/courses/spring09/mcguem/psy5993/readings/vandenoord2008.pdf
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Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism reports a personality genetics study. The study examined more than 420'000 genetic markers on 1227 healthy individuals with replication on a sample of 1880 healthy individuals.

The 1227 (1228?) individuals filled out the 12-item short version of the Eysenck Personality Questionnaire Neuroticism Scale, while the replication sample used NEO PI-R neuroticism scale.

The results on MAMDC1 was followed up in another study, Follow-up association study of novel neuroticism gene MAMDC1, with negative results.

[edit] Results

  1. Neuroticism and MAMDC1

[edit] See also

  1. Genome-wide association scan for five major dimensions of personality
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