Association study of catechol-O-methyltransferase gene and dopamine D4 receptor gene polymorphisms and personality traits in healthy young Chinese females

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Association study of catechol-O-methyltransferase gene and dopamine D4 receptor gene polymorphisms and personality traits in healthy young Chinese females
Authors: Shih-Jen Tsai, Chen-Jee Hong, Younger W.-Y. Yu, Tai-Jui Chen
Citation: Neuropsychobiology 50 (2): 153-156. 2004
Database(s): PubMed (PMID/15292670)
DOI: 10.1159/000079107.
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Association study of catechol-O-methyltransferase gene and dopamine D4 receptor gene polymorphisms and personality traits in healthy young chinese females reports a personality genetics study on genetic polymorphisms in the COMT and DRD4 genes and personality traits assessed with Tridimensional Personality Questionnaire.

[edit] Subjects

Subject group #1 (help)
Chinese female nursing students
Subjects/♂/♀: 120 / 0 / 120
Age: (19–21)
Nationality: Taiwanese
Approval: Institution Review Board of the Taipei Veterans General Hospital
Databases:

Group 1 of 120 chinese female nursing students with 0 males and 120 females were included in the study. The Taiwanese group was from 19 up to 21 years old. The study on the human subjects was approved by the Institution Review Board of the Taipei Veterans General Hospital.

[edit] Results

"short" in their analysis means less or equal to four repeats, while "long" means more than four.
Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
COMT met158val val/val TPQ Novelty seeking 19.0 4.6 71 Chinese female nursing students 15292670
COMT met158val val/val TPQ Reward dependence 18.5 4.1 71 Chinese female nursing students 15292670
COMT met158val val/val TPQ Harm avoidance 15.3 6.7 71 Chinese female nursing students 15292670
COMT met158val met/val TPQ Novelty seeking 16.7 4.7 43 Chinese female nursing students 15292670
COMT met158val met/val TPQ Reward dependence 20.4 3.1 43 Chinese female nursing students 15292670
COMT met158val met/val TPQ Harm avoidance 15.3 6.6 43 Chinese female nursing students 15292670
COMT met158val met/met TPQ Novelty seeking 15.2 5.5 6 Chinese female nursing students 15292670
COMT met158val met/met TPQ Reward dependence 17.0 3.0 6 Chinese female nursing students 15292670
COMT met158val met/met TPQ Harm avoidance 14.8 4.5 6 Chinese female nursing students 15292670
DRD4 Exon 3 VNTR short/short TPQ Novelty seeking 18.2 4.9 111 Chinese female nursing students 15292670
DRD4 Exon 3 VNTR short/short TPQ Reward dependence 19.2 3.8 111 Chinese female nursing students 15292670
DRD4 Exon 3 VNTR short/short TPQ Harm avoidance 15.4 6.9 111 Chinese female nursing students 15292670
DRD4 Exon 3 VNTR short/long TPQ Novelty seeking 16.1 3.9 9 Chinese female nursing students 15292670
DRD4 Exon 3 VNTR short/long TPQ Reward dependence 17.2 3.7 9 Chinese female nursing students 15292670
DRD4 Exon 3 VNTR short/long TPQ Harm avoidance 12.7 5.2 9 Chinese female nursing students 15292670

[edit] Related studies

The study is an extension of two previous studies of the authors:

  1. Assocaition study of a functional catechol-O-methylferase gene polymorphism and cognitive function in healthy females
  2. Personality traits in young female apolipoprotein E (apoE) epsilon4 and non-epsilon4 carriers
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