Negative association of neuroticism with brain volume ratio in healthy humans reports a magnetic resonance imaging study on the brain volume and its relation to personality.
The personality was assessed with the 240-item NEO PI-R and results are reported for the personality trait neuroticism and its facets.
A similar 2000 study examined brain volume related to Minnesota Multiphasic Personality Inventory.
Group 1 of 38 males with 38 males and 0 females were included in the study.
The American group had a mean age of 29.4 with a range from 19 to 45.
The study on the human subjects was approved by the National Institute on Alcohol Abuse and Alcoholism Institutional Review Board
Group 2 of 48 females with 0 males and 48 females were included in the study.
The American group had a mean age of 31.4 with a range from 19 to 45.
The study on the human subjects was approved by the National Institute on Alcohol Abuse and Alcoholism Institutional Review Board.
The demographics are given in Table 1.
The participants were of varying ethnicity.
 Brain volumes
Brain volumes without respect to the personality are given in Table 2, page 687. It has 2x6=12 brain volume values and 2x5=10 brain ratio values.
 Brain region and neuroticism correlation
- ↑ M. Matsui, R. C. Gur, B. I. Turetsky, M. X. Yan, R. E. Gur (2000). "The relation between tendency for psychopathology and reduced frontal brain volume in healthy people". Neuropsychiatry Neuropsychol Behav Neurol 13: 155-162.