Influence of SERTPR and STin2 in the serotonin transporter gene on the effect of selective serotonin reuptake inhibitors in depression: a systematic review

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Influence of SERTPR and STin2 in the serotonin transporter gene on the effect of selective serotonin reuptake inhibitors in depression: a systematic review
Authors: K. M. Smits, L. J. M. Smits, J. S. A. G. Schouten, F. F. Stelma, P. Nelemans, M. H. Prins
Citation: Molecular Psychiatry 9 (5): 433-441. 2004 May
Database(s): PubMed (PMID/15037864)
DOI: 10.1038/sj.mp.4001488.
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Influence of SERTPR and STin2 in the serotonin transporter gene on the effect of selective serotonin reuptake inhibitors in depression: a systematic review reports a systematic review of treatment response in relation to serotonin reuptake inhibitors, depression and the polymorphims 5-HTTLPR and STin2.

Related newer studies on depression treatment response and 5-HTTLPR was published in 2007 (a meta-analysis)[1] and 2009[2]

[edit] Critique

  1. In their abstract they state "...a less favourable response to SSRI treatment ... among (Asian) patients with the STin 10/12 genotype". However, their RR for response rate has an all too wide confidence ratio (0.07-3.05) to justify that statement.
  2. The review of STin2 is based on only two studies, where one study has only 54 subjects.

[edit] References

  1. A. Serretti, M. Kato, D. De Ronchi, T. Kinoshita (2007). "Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients". Molecular Psychiatry 12: 247–257. doi: 10.1038/sj.mp.4001926.
  2. Serotonin transporter promoter region polymorphisms do not influence treatment response to escitalopram in patients with major depression
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