Hippocampal volume in primary unipolar major depression: a magnetic resonance imaging study

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Hippocampal volume in primary unipolar major depression: a magnetic resonance imaging study
Authors: Khashayar Vakili, Srinivasan S. Pillay, Beny Lafer, Maurizio Fava, Perry F. Renshaw, Christina M. Bonello-Cintron, Deborah A. Yurgelun-Todd
Citation: Biological Psychiatry 47 : 1087-1090. 2000
Database(s): Bibliographics or graphical review in IBVD PubMed (PMID/10862809)
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Hippocampal volume in primary unipolar major depression: a magnetic resonance imaging study reports a magnetic resonance imaging study on the hippocampal volume of patients with primary unipolar major depression and controls.

Hippocampal boundaries was determined based on Sheline et al 1996.[1]

[edit] Subjects

Subject group #1 (help)
Primary unipolar major depression patients
Subjects/♂/♀: 38 / 17 / 21
Age: 38.5 ±10.0 (–)
Nationality: American
Approval: Institutional Review Board of Massachusetts General Hospital
Databases:

Group 1 of 38 primary unipolar major depression patients with 17 males and 21 females were included in the study. The American group had a mean age of 38.5.

The study on the human subjects was approved by the Institutional Review Board of Massachusetts General Hospital.
Subject group #2 (help)
Controls
Description: Healthy control subjects matched for sex, age and education
Subjects/♂/♀: 20 / 9 / 11
Age: 40.2 ±10.4 (–)
Nationality: American
Approval: Institutional Review Board of Massachusetts General Hospital
Databases:

Group 2 of 20 controls with 9 males and 11 females were included in the study. The American group had a mean age of 40.2. The study on the human subjects was approved by the Institutional Review Board of Massachusetts General Hospital. Patients meeting criteria for major depressive disorder with Structured Clinical Interview for Diagnosis where recruited in connection with a double-blind study of medical treatment.

The number of females in the control group is not clearly written, but from the context it is probably 11 female of 20 controls.

[edit] Results

It is not entirely clear whether the variation reported is the standard deviation or the standard error of the mean.

Table 1, part 1.
#
Mean
Std
SEM
Unit
Anatomy
Group
No. (M/F)
Age
1 2.64 ml Left hippocampus Primary unipolar major depression patients 38 (17/21) 38.5 ±10.0 (–)
2 2.46 ml Left hippocampus Control subjects 20 (9/11) 40.2 ±10.4 (–)
3 2.61 ml Right hippocampus Primary unipolar major depression patients 38 (17/21) 38.5 ±10.0 (–)
4 2.60 ml Right hippocampus Control subjects 20 (9/11) 40.2 ±10.4 (–)
Entry not completed (help)
There are further results than the absolute volume for the groups: Relative to the total cerebral volume, correlation with Hamilton Depression Rating Scale scores and comparison between responders and non-responders to treatment.
#
Mean
Std
SEM
Unit
Anatomy
Group
No. (M/F)
Age
Entry not completed (help)

[edit] References

  1. Y. I. Sheline, P. W. Wang, M. H. Gado, J. G. Csernansky, M. W. Vannier (1996). "Hippocampal atrophy in recurrent major depression". Proceedings of the National Academy of Sciences of the United States of America 93: 3908-3913.
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