Genetic contributions to age-related decline in executive function: a 10-year longitudinal study of COMT and BDNF polymorphisms
|Genetic contributions to age-related decline in executive function: a 10-year longitudinal study of COMT and BDNF polymorphisms|
|Authors:||Kirk I. Erickson, Jennifer S. Kim, Barbara L. Suever, Michelle W . Voss, B. Magnus Francis, Arthur F . Kramer|
|Citation:||Frontiers in Human Neuroscience 2 : 11. 2009|
|Web:||Bing Google Yahoo! — Google PDF|
|Article:||BASE Google Scholar PubMed|
|Restricted:||DTU Digital Library|
|Format:||BibTeX Template from PMID|
|Extract:||Talairach coordinates from linked PDF: CSV-formated wiki-formated|
Genetic contributions to age-related decline in executive function: a 10-year longitudinal study of COMT and BDNF polymorphisms reports a genetic association study with polymorphims in the BDNF (Val66met) and the COMT genes and cognitive decline over a 10 year period.
They argue that BDNF.val66met.val/val has more cognitive descline over time.
- There are rather few subjects in the study compared to other genetic association studies: Only 53 subjects. And six of those participants could not complete one of the tasks.
- In defense of the authors the six that could not complete the task were all BDNF.val66met.val/val, thus the dropout is in line with the argument of the authors.
- The effect of BDNF.val66met.val/val shows up in an interaction test — not a direct independent t-test (page 7, column 1, paragraph 2).