Genetic contributions to age-related decline in executive function: a 10-year longitudinal study of COMT and BDNF polymorphisms

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Genetic contributions to age-related decline in executive function: a 10-year longitudinal study of COMT and BDNF polymorphisms
Authors: Kirk I. Erickson, Jennifer S. Kim, Barbara L. Suever, Michelle W . Voss, B. Magnus Francis, Arthur F . Kramer
Citation: Frontiers in Human Neuroscience 2 : 11. 2009
Database(s): PubMed (PMID/18958211)
DOI: doi:10.3389/neuro.09.011.2008.
Link(s): http://www.frontiersin.org/humanneuroscience/paper/10.3389/neuro.09/011.2008/
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Genetic contributions to age-related decline in executive function: a 10-year longitudinal study of COMT and BDNF polymorphisms reports a genetic association study with polymorphims in the BDNF (Val66met) and the COMT genes and cognitive decline over a 10 year period.

They argue that BDNF.val66met.val/val has more cognitive descline over time.

[edit] Critique

  1. There are rather few subjects in the study compared to other genetic association studies: Only 53 subjects. And six of those participants could not complete one of the tasks.
    1. In defense of the authors the six that could not complete the task were all BDNF.val66met.val/val, thus the dropout is in line with the argument of the authors.
  2. The effect of BDNF.val66met.val/val shows up in an interaction test — not a direct independent t-test (page 7, column 1, paragraph 2).
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