Dopamine D4 receptor gene

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Dopamine D4 receptor gene
Abbreviations: DRD4
Category: Dopamine D4 receptor gene

Dopamine system

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Dopamine D4 receptor gene (DRD4).


[edit] Polymorphisms

There are several polymorphisms[1]

  1. Rs1800955, C-521T
  2. Exon 3 VNTR, 48-bp
  3. Exon 1 12-bp repeat[2]
  4. rs1800443, Gly194val[3]
  5. rs4646984 a polymorphic tandem 120-bp duplication in the promoter[4]
  6. 13-bp deletion of bases 235 to 247 in exon 1[5]
  7. Smal
  8. Pstl
  9. C-616G
  10. A-809G

[edit] Papers

[edit] Personality genetics

[edit] Meta-analysis

  1. A meta-analysis of the association between DRD4 polymorphism and novelty seeking
  2. Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data
  3. DRD4 and novelty seeking: results of meta-analyses
  4. Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis

[edit] Original research

  1. An examination of the association between DRD4 and DRD2 polymorphisms and personality traits
  2. Association between novelty seeking and the -521 C/T polymorphism in the promoter region of the DRD4 gene
  3. Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients
  4. Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data
  5. Association study of catechol-O-methyltransferase gene and dopamine D4 receptor gene polymorphisms and personality traits in healthy young Chinese females
  6. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking
  7. Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait
  8. Neuroendocrine support for a relationship between 'novelty seeking' and dopaminergic function in alcohol-dependent men
  9. Personality, Dopamine Receptor D4 Exon III Polymorphisms, and Academic Achievement in Medical Students
  10. Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking
  11. The association between the dopamine D(4) receptor (D4DR) 16 amino acid repeat polymorphism and novelty seeking
  12. The DRD4 gene and the spiritual transcendence scale of the character temperament index

[edit] References

  1. Hiroshi Mitsuyasu, Hidetoshi Ozawa, Yasuhiko Takeda1, Yasuyuki Fukumaki (1999). "Novel polymorphisms in the upstream region of the human dopamine D4 receptor (DRD4) gene". Journal of Human Genetics 44(6): 416-418. doi: 10.1007/s100380050191.
  2. M. Catalano, M. Nobile, E. Novelli, M. M. Nöthen, E. Smeraldi (1993). "Distribution of a novel mutation in the first exon of the human dopamine D4 receptor gene in psychotic patients". Biological Psychiatry 34(7): 459-464. doi: 10.1016/0006-3223(93)90236-7. PMID: 8268330.
  3. missing author1 (missing year). "Dopamine D4 receptor variant, D4GLYCINE194, in Africans, but not in Caucasians: no association with schizophrenia". Am. J. Med. Genet. 54: 384.
  4. M. I. Seaman (1999). "Tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4)". Am J Med Genet. 88(6): 705-709.
  5. M. M. Nöthen (1994). "Human dopamine D4 receptor gene: frequent occurrence of a null allele and observation of homozygosity". Hum. Mol. Genet. missing volume: missing pages.
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