Center for Integrated Molecular Brain Imaging

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Center for Integrated Molecular Brain Imaging (CIMBI)
Location: Copenhagen, Denmark Map
Homepage: http://www.cimbi.dk
Database(s): Mendeley group
Funded by: Lundbeck Foundation
Parent(s): Research center
Child(ren): CIMBI-36
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Center for Integrated Molecular Brain Imaging (CIMBI) is a Danish research center funded by the Lundbeck Foundation and investigates interindividual differences with the neuroimaging techniques positron emission tomography and magnetic resonance imaging including fMRI as well as other techniques such as personality inventories, neuropsychological testing and genetic testing, e.g., Cimbi Affective Memory Test. Molecular neuroimaging radiotracers available in the project are targeted towards, e.g., the serotonin-2A receptor (with altanserin and CIMBI-36), serotonin-7 receptor and the serotonin transporter (with DASB).

Among the participating organizations are Neurobiology Research Unit, Danish Research Centre for Magnetic Resonance, DTU Informatics at the Technical University of Denmark and the University of Copenhagen.

Contents

[edit] People

[edit] Steering group

See also [2]

[edit] Former members of the steering group

[edit] Researchers

Among the researchers affiliated within the CIMBI center are

  1. Agnete Overgaard
  2. Anders Bue Klein
  3. Anders Ettrup
  4. Bettina Hornbøll
  5. Brenda Elvira Munk McMahon
  6. Camilla Borgsted Larsen
  7. Christian Gaden Jensen
  8. Claus Svarer
  9. David Erritzøe
  10. David Meder
  11. Dea Siggaard Stenbæk
  12. Finn Årup Nielsen
  13. Hanne Demant Hansen
  14. Jacob Madsen
  15. Jens Damsgaard Mikkelsen
  16. Jesper Langgaard Kristensen
  17. Julian Macoveanu
  18. Kathrine Skak Madsen
  19. Klaus Kähler Holst
  20. Lars Kai Hansen
  21. Liv Vadskjær Hjordt Hansen
  22. Martin Korsbak Hansen
  23. Matthias Herth
  24. Melanie Ganz-Benjaminsen
  25. Mette Haahr
  26. Patrick M. Fisher
  27. Pernille Iversen
  28. Sophie da Cunha-Bang
  29. Susanne Henningsson
  30. Terry L. Jernigan
  31. Valdemar L. Andersen
  32. Vibe Gedsø Frøkjær
  33. Vincent Beliveau
  34. William F. C. Baaré

[edit] Former members

  1. Bartłomiej Wilkowski
  2. Carsten Stahlhut
  3. Jan Kalbitzer
  4. Susana Aznar

[edit] External

[edit] International collaborators/advisors

[edit] Research

Among the ligands used in PET by the center are altanserin, DASB and SB207145.[1] The pharmacological group has also developed CIMBI5 (5-HT2A agonists)[2] as well as CIMBI-36.

Among the tools developed are the Brede Toolbox, Brede Wiki, SKEEPMED and smartphone EEG.

[edit] Papers

Among the papers from CIMBI are:

  1. A cure for variance inflation in high dimensional kernel principal component analysis (2011)
  2. A fielded wiki for personality genetics
  3. A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans
  4. A probabilistic approach to delineating functional brain regions
  5. A smartphone interface for a wireless EEG headset with real-time 3D reconstruction (2011)
  6. Acute serotonin 2A receptor blocking alters the processing of fearful faces in the orbitofrontal cortex and amygdala
  7. BDNF val66met and 5-HTTLPR polymorphisms predict a human in vivo marker for brain serotonin levels
  8. Brain serotonin 2A receptor binding: relations to body mass index, tobacco and alcohol use
  9. Bridging the gap between coordinate- and keyword-based search of neuroscientific databases by UMLS-assisted semantic keyword extraction
  10. Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels
  11. Cortisol awakening response and negative emotionality linked to asymmetry in major limbic fibre bundle architecture
  12. Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia
  13. Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder
  14. Functional and molecular neuroimaging of menopause and hormone replacement therapy
  15. Gender and the use of hormonal contraception in women are not associated with cerebral cortical 5-HT 2A receptor binding
  16. Graph-based methods for discovery browsing with semantic predications
  17. High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding
  18. In vivo PET imaging of cerebral 5-HT7 receptors with a novel radioligand
  19. Learning the solution sparsity of an ill-posed linear inverse problem with the variational garrote
  20. Lost in localization: a solution with neuroinformatics 2.0?
  21. Measurements of brain-derived neurotrophic factor: methodological aspects and demographical data
  22. Mobile real-time EEG imaging Bayesian inference with sparse, temporally smooth source priors (2013)
  23. Model selection for Gaussian kernel PCA denoising (2012)
  24. Model sparsity and brain pattern interpretation of classication models in neuroimaging
  25. Online open neuroimaging mass meta-analysis (2012)
  26. Personality characteristics in surgery seeking and non-surgery seeking obese individuals compared to non-obese controls
  27. Regularized pre-image estimation for kernel PCA de-noising. Input space regularization and sparse reconstruction (2011)
  28. Seasonal changes in brain serotonin transporter binding in short 5-HTTLPR-allele carriers but not in long-allele homozygotes
  29. Serotonin 2A receptor agonist binding in the human brain with (11C)Cimbi-36
  30. Serotonin 2A receptors contribute to the regulation of risk-averse decisions
  31. Simultaneous EEG source and forward model reconstruction (SOFOMORE) using a hierarchical Bayesian approach
  32. Smartphones get emotional: mind reading images and reconstructing the neural sources
  33. Sparse non-linear denoising: generalization performance and pattern reproducibility in functional MRI (2011)
  34. Sparse source EEG imaging with the variational garrote (2013)
  35. The 5-HT2A receptor binding pattern in the human brain is strongly genetically determined
  36. The Center for Integrated Molecular Brain Imaging (Cimbi) database
  37. Variance inflation in high dimensional support vector machines
  38. Finn Årup Nielsen (2009). "Visualizing data mining results with the Brede tools". Frontiers in Neuroinformatics 3: 26. doi: 10.3389/neuro.11/026.2009.
  39. Visualization of nonlinear kernel models in neuroimaging by sensitivity maps (2011)
  40. What to measure next to improve decision making? On top-down task driven feature saliency (2011)

[edit] Meeting abstracts

  1. Pilot study on receptor binding and serotonin sensitivity of (11C)CIMBI-36 in monkey brain

[edit] References

  1. Birgitte R. Kornum, N. M. Lind, N. Gillings, Lisbeth Marner, F. Andersen, Gitte Moos Knudsen (2009). "Evaluation of the novel 5-HT4 receptor PET ligand (11C)SB207145 in the Göttingen minipig". J Cereb Blood Flow Metab 29(1): 186-196.
  2. Anders Ettrup, Mikael Palner, Nic Gillings, Kjell Nagren, Sune Keller, Merence Sibomana, Lars Rasmussen, Jacob Madsen, Mikael Begtrup, Gitte Moos Knudsen (2009). "(11C)-CIMBI5: A novel 5-HT2A agonist PET tracer". Journal of Nuclear Medicin 50 (supplement 2): 490. [1].
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