A unified model for functional and statistical epistasis and its application in quantitative trait loci analysis
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A unified model for functional and statistical epistasis and its application in quantitative trait loci analysis | |
Authors: | José M. Álvarez-Castro, Örjan Carlborg |
Citation: | Genetics 176 : 1151-1167. 2007 June |
Database(s): | Google Scholar cites |
DOI: | 10.1534/genetics.106.067348. |
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Restricted: | DTU Digital Library |
Other: | NIF |
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A unified model for functional and statistical epistasis and its application in quantitative trait loci analysis presents a framework for analysis of genetic interactions (epistasis). The call their framework "natural and orthogonal interactions" (NOIA).
The model is based on Zeng et al.^{[1]}
The present the "genetic-effect design matrix":
- <math>\mathbf{S} = \left[\begin{matrix} 1 & 0 & 0 \\ 1 & 1 & 1 \\ 1 & 2 & 0 \end{matrix}\right]</math>