WOROI: 97 - Anterior insula
 
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WOROI: 97 - Anterior insula


External databases

Taxonomy

ParentsSiblingsChildren
Insula
Economo-Koskinas area IA
Left anterior insula
Right anterior insula

Talairach coordinates

  x     y     z   Lobar anatomy WOBIB WOEXP
-30 16 7 Anterior insula 8 16
28 23 3 Right anterior insula 17 50
36 5 13 Right anterior insula 17 50
-40 2 2 Left anterior insula 23 72
40 8 1 Right anterior insula 23 75
-30 20 4 Left anterior insula 35 118
-30 22 0 Left anterior insula 35 120
32 13 18 Right anterior insula 56 180
32 13 18 Right anterior insula 56 181
40 9 0 Anterior insula 57 182
-40 18 6 Anterior insula 57 183
36 -12 12 Right Mid-/anterior insula 58 184
-38 -4 0 Left Mid-/anterior insula 58 184
36 18 4 Right anterior insula 60 186
-30 24 5 Left anterior insula 60 186
42 19 -6 Right anterior insula 60 188
-36 22 -4 Left anterior insula 60 188
-33 16 -8 Anterior insula 62 193
-31 14 -6 Anterior insula 62 195
28 18 -4 Right anterior insula 68 209
35 31 9 Right anterior insula 71 223
46 11 9 Right anterior insula 71 223
-32 22 15 Left anterior insula 71 223
38 17 9 Right anterior insula 71 224
-33 23 7 Anterior insula 95 298
38 6 9 Anterior insula 117 362
-31 5 5 Ipsilateral anterior insula 117 362
42 15 9 Anterior insula 117 366
-33 1 0 Anterior insula 118 368
27 18 10 Right anterior insula 148 456
41 9 12 Right anterior insula 149 457
40 13 13 Right anterior insula 149 459
33 8 -8 Anterior insula 178 557
-34 8 -6 Anterior insula 178 560
37 16 9 Right anterior insula 178 561
-32 16 10 Left anterior insula 178 561

Summary

  x     y     z   Description
-33 14 2 Mean coordinate in left hemisphere
36 13 7 Mean coordinate in right hemisphere
35 13 5 Mean coordinate with ignored left/right
27 -12 -8 Minimum coordinate with ignored left/right
46 31 18 Maximum coordinate with ignored left/right
5 9 7 Standard deviation with ignored left/right
corner cube of WOROI: 97 - Anterior insula

Text contexts

In accord with previous studies, the results showed that being aware of causing an action was associated with activation in the anterior insula, whereas being aware of not causing the action and attributing it to another person was associated with activation in the inferior parietal cortexChl÷Ú Farrer; Chris D. Frith. Experiencing oneself vs another person as being the cause of an action: the neural correlates of the experience of agency. NeuroImage 15(3):596-603, 2002. PMID: 11848702. DOI: 10.1006/nimg.2001.1009. WOBIB: 23.
We suggest that the anterior insula is concerned with the integration of all the concordant multimodal sensory signals associated with voluntary movementsChl÷Ú Farrer; Chris D. Frith. Experiencing oneself vs another person as being the cause of an action: the neural correlates of the experience of agency. NeuroImage 15(3):596-603, 2002. PMID: 11848702. DOI: 10.1006/nimg.2001.1009. WOBIB: 23.
Notably, perceived thermal intensity was well correlated with activation in the right (ipsilateral) anterior insular and orbitofrontal corticesA. D. Craig; K. Chen; D. Bandy; Eric M. Reiman. Thermosensory activation of insular cortex. Nature Neuroscience 3(2):184-190, 2000. PMID: 10649575. DOI: 10.1038/72131. WOBIB: 56.
With attention diverted from the painful stimulus bilateral anterior insula activity moved posteriorly to midinsula and decreased in extent (ROI analysis: significant main effect of attention (P = 0Jonathan C. W. Brooks; Turo J. Nurmikko; William E. Bimson; Krish D. Singh; Neil Roberts. fMRI of thermal pain: effects of stimulus laterality and attention. NeuroImage 15(2):293-301, 2002. PMID: 11798266. DOI: 10.1006/nimg.2001.0974. WOBIB: 60.
Comparing baseline scans during pain with scans taken after stimulation, when the patient had become pain-free, revealed significant rCBF increases in the prefrontal (Brodmann areas (BA) 9, 10, 11 and 47) and anterior insular cortices, hypothalamus and periaqueductal gray associated with the presence of chronic painR. C. Kupers; J. M. Gybels; Albert Gjedde. Positron emission tomography study of a chronic pain patient successfully treated with somatosensory thalamic stimulation. Pain 87(3):295-302, 2000. PMID: 10963909. WOBIB: 62.
During thalamic stimulation, blood flow significantly increased in the amygdala and anterior insular cortexR. C. Kupers; J. M. Gybels; Albert Gjedde. Positron emission tomography study of a chronic pain patient successfully treated with somatosensory thalamic stimulation. Pain 87(3):295-302, 2000. PMID: 10963909. WOBIB: 62.
Both strong and mild expressions of disgust activated anterior insular cortex but not the amygdala; strong disgust also activated structures linked to a limbic cortico-striatal-thalamic circuitMary L. Phillips; A. W. Young; C. Senior; M. Brammer; C. Andrew; A. J. Calder; E. T. Bullmore; D. I. Perrett; D. Rowland; Steven C. R. Williams; J. A. Gray; Anthony S. David. A specific neural substrate for perceiving facial expressions of disgust. Nature 389(6650):495-8, 1997. PMID: 9333238. DOI: 10.1038/39051. WOBIB: 71.
Some cortical, but not subcortical, structures showed significant or borderline activation only during the early scans (ipsilateral premotor cortex, contralateral perigenual anterior cingulate, lateral prefrontal, and anterior insular cortex); they may mediate pain-related attentive or anticipatory functionsK. L. Casey; T. J. Morrow; J. Lorenz; S. Minoshima. Temporal and spatial dynamics of human forebrain activity during heat pain: analysis by positron emission tomography. Journal of Neurophysiology 85(2):951-9, 2001. PMID: 11160525. WOBIB: 95.
Significant activity also appeared within the region of the contralateral anterior insula and lenticular nucleusK. L. Casey; S. Minoshima; T. J. Morrow; R. A. Koeppe. Comparison of human cerebral activation pattern during cutaneous warmth, heat pain, and deep cold pain. Journal of Neurophysiology 76(1):571-81, 1996. PMID: 8836245. WOBIB: 102.
Painful stimulation produced contralateral activation in primary and secondary somatosensory cortices (SI and SII), anterior cingulate cortex, anterior insula, the supplemental motor area of the frontal cortex, and thalamusR. C. Coghill; J. D. Talbot; A. C. Evans; Ernst Meyer; Albert Gjedde; M. C. Bushnell; G. H. Duncan. Distributed processing of pain and vibration by the human brain. Journal of Neuroscience 14(7):4095-108, 1994. PMID: 8027764. WOBIB: 117.
In contrast, painful stimuli were significantly more effective in activating the anterior insula, a region heavily linked with both somatosensory and limbic systemsR. C. Coghill; J. D. Talbot; A. C. Evans; Ernst Meyer; Albert Gjedde; M. C. Bushnell; G. H. Duncan. Distributed processing of pain and vibration by the human brain. Journal of Neuroscience 14(7):4095-108, 1994. PMID: 8027764. WOBIB: 117.
Unfair offers elicited activity in brain areas related to both emotion (anterior insula) and cognition (dorsolateral prefrontal cortex)Alan G. Sanfey; James K. Rilling; Jessica A. Aronson; Leigh E. Nystrom; Jonathan D. Cohen. The Neural Basis of Economic decision-Making in the Ultimatum Game. Science 300(5626):1755-1758, 2003. PMID: 12805551. DOI: 10.1126/science.1082976. FMRIDCID: . WOBIB: 179.
Further, significantly heightened activity in anterior insula for rejected unfair offers suggests an important role for emotions in decision-makingAlan G. Sanfey; James K. Rilling; Jessica A. Aronson; Leigh E. Nystrom; Jonathan D. Cohen. The Neural Basis of Economic decision-Making in the Ultimatum Game. Science 300(5626):1755-1758, 2003. PMID: 12805551. DOI: 10.1126/science.1082976. FMRIDCID: . WOBIB: 179.

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Bib -> Asymmetry | Author | ICA | NMF | Novelty | Statistics | SVD | Title | WOBIB ]
Roi -> Alphabetic | Hammers | Tzourio-Mazoyer | Svarer | Top | Functional areas | Brodmann areas ]
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