WOROI: 40 - Hippocampus
 
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WOROI: 40 - Hippocampus

The hippocampus (proper) is part of the hippocampal formation, and the hippocampus proper consists of the three 'fields' CA1, CA2 and CA3.

Abbreviation: Hi

Variation: Hippocampus proper
Variation: Cornu ammonis

External databases

BrainInfo: 164
IBVD: Hippocampus
Wikipedia: Hippocampus
ICBM Label: 93

Taxonomy

ParentsSiblingsChildren
Hippocampal formation
Amygdala and Hippocampus
Medial temporal lobe
  Left hippocampus
Right hippocampus
CA1 field

Talairach coordinates

  x     y     z   Lobar anatomy WOBIB WOEXP
-30 -37 6 Left hippocampus 14 42
30 -16 -18 Right hippocampus 38 126
30 -20 -12 Right hippocampus 38 127
-16 -25 -4 Left hippocampus 38 127
36 -12 -16 Right hippocampus 38 128
-38 -33 -7 Left posterior hippocampus 54 176
36 -29 0 Right posterior hippocampus 54 176
31 -22 -10 Right hippocampus 63 196
-31 -28 -7 Left hippocampus 63 196
32 -8 -23 Right hippocampus 63 197
-24 -8 -21 Left hippocampus 63 197
-23 -20 -11 Left hippocampus 73 228
25 -20 -12 Right hippocampus 73 228
-22 -12 -11 Left hippocampus 78 243
-28 -16 -13 Left hippocampus 78 244
-24 -14 -13 Hippocampus 93 295
-20 -30 0 Left hippocampus 104 323
-22 -20 -12 Left hippocampus 121 374
12 -25 -2 Left hippocampus 126 389
-2 -80 1 Lingual gyrus (parahippocampus) 126 391
34 -40 4 Near tail of caudate and hippocampus 130 403
26 -13 -25 Right subiculum/hippocampus 131 405
-22 -26 -12 Left hippocampus 142 434
28 -16 -18 Right anterior hippocampus 142 435
30 -14 -13 Right hippocampus 146 447
24 -14 -13 Right anterior hippocampus 146 448
36 -16 -16 Right hippocampus/perirhinal 152 468
-16 -29 -5 Left hippocampus 152 468
-34 -26 -9 Left hippocampus 152 468
36 -17 -19 Right hippocampus/perirhinal 152 469
-34 -41 -3 Left parahippocampus 168 515
-2 -42 0 Left hippocampus 182 574
12 -38 4 Right hippocampus 182 574
0 -42 0 Left hippocampus 182 575
12 -38 4 Right hippocampus 182 575
-26 -37 -5 Left posterior hippocampus 184 579

Summary

  x     y     z   Description
-23 -29 -7 Mean coordinate in left hemisphere
27 -21 -11 Mean coordinate in right hemisphere
24 -26 -9 Mean coordinate with ignored left/right
0 -80 -25 Minimum coordinate with ignored left/right
38 -8 6 Maximum coordinate with ignored left/right
10 14 8 Standard deviation with ignored left/right
corner cube of WOROI: 40 - Hippocampus

Text contexts

The musical instrument stimuli mainly activated areas in visual association cortex, cerebellum, and the hippocampusK. Hugdahl; Ian Law; S. Kyllingsbaek; K. Bronnick; Anders Gade; Olaf B. Paulson. Effects of attention on dichotic listening: an 15O-PET study. Human Brain Mapping 10(2):87-97, 2000. PMID: 10864233. WOBIB: 14.
Activation of the right hippocampus was strongly associated with knowing accurately where places were located and navigating accurately between themE. A. Maguire; N. Burgess; J. G. Donnett; Richard S. J. Frackowiak; C. D. Frith; J. O'Keefe. Knowing where and getting there: a human navigation network. Science 280(5365):921-4, 1998. PMID: 9572740. WOBIB: 38.
These two right-side brain structures function in the context of associated activity in right inferior parietal and bilateral medial parietal regions that support egocentric movement through the virtual town, and activity in other left-side regions (hippocampus, frontal cortex) probably involved in nonspatial aspects of navigationE. A. Maguire; N. Burgess; J. G. Donnett; Richard S. J. Frackowiak; C. D. Frith; J. O'Keefe. Knowing where and getting there: a human navigation network. Science 280(5365):921-4, 1998. PMID: 9572740. WOBIB: 38.
Hippocampal volume correlated with the amount of time spent as a taxi driver (positively in the posterior and negatively in the anterior hippocampus)E. A. Maguire; D. G. Gadian; I. S. Johnsrude; C. D. Good; J. Ashburner; Richard S. J. Frackowiak; C. D. Frith. Navigation-related structural change in the hippocampi of taxi drivers. Proc Natl Acad Sci U S A 97(8):4398-403, 2000. PMID: 10716738. DOI: 10.1073/pnas.070039597. WOBIB: 63.
These data are in accordance with the idea that the posterior hippocampus stores a spatial representation of the environment and can expand regionally to accommodate elaboration of this representation in people with a high dependence on navigational skillsE. A. Maguire; D. G. Gadian; I. S. Johnsrude; C. D. Good; J. Ashburner; Richard S. J. Frackowiak; C. D. Frith. Navigation-related structural change in the hippocampi of taxi drivers. Proc Natl Acad Sci U S A 97(8):4398-403, 2000. PMID: 10716738. DOI: 10.1073/pnas.070039597. WOBIB: 63.
It has been argued that the role of the hippocampus in memory is time-limited: during a period of memory consolidation, other brain regions such as the neocortex are said to acquire the ability to support memory retention and retrieval on their ownL. Ryan; L. Nadel; K. Keil; K. Putnam; D. Schnyer; T. Trouard; M. Moscovitch. Hippocampal complex and retrieval of recent and very remote autobiographical memories: evidence from functional magnetic resonance imaging in neurologically intact people. Hippocampus 11(6):707-14, 2001. PMID: 11811665. WOBIB: 73.
Within this system, however, enhanced activity was observed for retrieval of personally relevant, time-specific memories in left hippocampus, medial prefrontal cortex, and left temporal poleE. A. Maguire; C. J. Mummery. Differential modulation of a common memory retrieval network revealed by positron emission tomography. Hippocampus 9(1):54-61, 1999. PMID: 10088900. WOBIB: 78.
We believe that these findings throw new light on an old debate surrounding episodic and declarative theories of memory and the precise involvement of the hippocampusE. A. Maguire; C. J. Mummery. Differential modulation of a common memory retrieval network revealed by positron emission tomography. Hippocampus 9(1):54-61, 1999. PMID: 10088900. WOBIB: 78.
Unpleasant was distinguished from neutral or pleasant emotion by activation of the bilateral occipito-temporal cortex and cerebellum, and left parahippocampal gyrus, hippocampus and amygdala (P < 0Richard D. Lane; Eric M. Reiman; M. M. Bradley; P. J. Lang; Geoffrey L. Ahern; Richard J. Davidson; Gary E. Schwartz. Neuroanatomical correlates of pleasant and unpleasant emotion. Neuropsychologia 35(11):1437-44, 1997. PMID: 9352521. BrainMap: 276. WOBIB: 93.
The group showed significant positive correlations between symptom intensity and blood flow in the right inferior frontal gyrus, caudate nucleus, putamen, globus pallidus and thalamus, and the left hippocampus and posterior cingulate gyrusPhilip K. McGuire; C. J. Bench; C. D. Frith; I. M. Marks; Richard S. J. Frackowiak; R. J. Dolan. Functional anatomy of obsessive-compulsive phenomena. British Journal of Psychiatry 164(4):459-468, 1994. PMID: 8038933. WOBIB: 104.
It is hypothesised that the increases in rCBF in the orbitofrontal cortex, neostriatum, global pallidus and thalamus were related to urges to perform compulsive movements, while those in the hippocampus and posterior cingulate cortex corresponded to the anxiety that accompanied themPhilip K. McGuire; C. J. Bench; C. D. Frith; I. M. Marks; Richard S. J. Frackowiak; R. J. Dolan. Functional anatomy of obsessive-compulsive phenomena. British Journal of Psychiatry 164(4):459-468, 1994. PMID: 8038933. WOBIB: 104.
Animal models of anxiety involving exposure to chronic stress have shown a specific decrease in benzodiazepine receptor binding in frontal cortex and hippocampusJ. D. Bremner; R. B. Innis; T. White; M. Fujita; D. Silbersweig; A. W. Goddard; L. Staib; E. Stern; A. Cappiello; S. Woods; R. Baldwin; D. S. Charney. SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder. Biological Psychiatry 47(2):96-106, 2000. PMID: 10664825. WOBIB: 126.
RESULTS: A decrease in measures of benzodiazepine receptor binding (DV) was found in left hippocampus and precuneus in panic disorder patients relative to controlsJ. D. Bremner; R. B. Innis; T. White; M. Fujita; D. Silbersweig; A. W. Goddard; L. Staib; E. Stern; A. Cappiello; S. Woods; R. Baldwin; D. S. Charney. SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder. Biological Psychiatry 47(2):96-106, 2000. PMID: 10664825. WOBIB: 126.
RESULTS: REC AN women had significantly reduced [18F]altanserin binding relative to CW in mesial temporal (amygdala and hippocampus), as well as cingulate cortical regionsGuido K. Frank; Walter H. Kaye; Carolyn C. Meltzer; Julie C. Price; Phil Greer; Claire McConaha; Kelli Skovira. Reduced 5-HT2A receptor binding after recovery from anorexia nervosa. Biological Psychiatry 52(9):896-906, 2002. PMID: 12399143. FMRIDCID: . WOBIB: 131.
Although the participants were unaware of the stimuli, activity in the hippocampus and perirhinal cortex was changed in the experimental versus the control condition; perirhinal activity changes correlated with the reaction time measure of the later nonconscious retrievalKatharina Henke; Christian R. A. Mondadori; Valerie Treyer; Roger M. Nitsch; Alfred Buck; Christoph Hock. Nonconscious formation and reactivation of semantic associations by way of the medial temporal lobe. Neuropsychologia 41(8):863-876, 2003. PMID: 12667523. FMRIDCID: . WOBIB: 152.
Remarkably, activity in the hippocampus and perirhinal cortex was enhanced when subjects were confronted with faces from the experimental versus the control conditionKatharina Henke; Christian R. A. Mondadori; Valerie Treyer; Roger M. Nitsch; Alfred Buck; Christoph Hock. Nonconscious formation and reactivation of semantic associations by way of the medial temporal lobe. Neuropsychologia 41(8):863-876, 2003. PMID: 12667523. FMRIDCID: . WOBIB: 152.
Duringpointing to the previous,instead, there was additional activation of supplementary motor cortex, anterior and midcingulate, and inferior occipital gyrus in the left hemisphere; superior parietal lobule, supramarginal gyrus, and posterior hippocampus in the right hemisphere; lingual gyri and cerebellar hemispheres bilaterally; anterior thalamus; and pulvinarF. Lacquaniti; Daniela Perani; E. Guigon; V. Bettinardi; M. Carrozzo; F. Grassi; Yves Rossetti; F. Fazio. Visuomotor Transformations for Reaching to Memorized Targets: A PET study. NeuroImage 5(2):129-146, 1997. PMID: 9345543. DOI: 10.1006.nimg.1996.0254. FMRIDCID: . WOBIB: 182.

Text count

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