WOBIB: 168 - Maddock, et al. (2003) Brain regions showin ...
 
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Richard J. Maddock; Michael H. Buonocore; Shawn J. Kile; Amy S. Garrett. Brain regions showing increased activation by threat-related words in panic disorder. NeuroReport 14(3):325-328, 2003. PMID: 12634477. FMRIDCID: . WOBIB: 168.

Threat-related stimuli consistently activate the posterior cingulate cortex in normal subjects and have exaggerated effects on memory in patients with panic disorder. We hypothesized that panic patients would show increased response to threat-related stimuli in the posterior cingulate cortex. While undergoing fMRI, six panic patients and eight healthy volunteers made valence judgements of threat-related and neutral words. Both groups showed threat-related activation in the left posterior cingulate and left middle frontal cortices, but the activation was significantly greater in panic patients. Panic patients also had more right>left asymmetry of activation in the mid-parahippocampal region. The increased responsivity observed in the posterior cingulate and dorsolateral prefrontal cortices is consistent with the hypothesis that panic disorder patients engage in more extensive memory processing of threat-related stimuli.

Asymmetry: -0.45117 (left: -1, right: +1)

VRML2 file (73 Kb)

1 Threat-related words in panic disorder patients versus controls. Panic disorder patients listening to threat-related words and making silent judgment on the valence versus listening to neutral words and listening to threat-related words in control subjects. WOEXP: 514.
2 Threat-related words in controls versus panic disorder patients. Control subjects listening to threat-related words and making silent judgment on the valence versus listening to neutral words and listening to threat-related words in panic disorder patients. WOEXP: 515.


corner cube of WOBIB_168

Related - positive correlated volumes

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+2: 0.54465 R. J. Maddock; A. S. Garrett; Michael H. Buonocore. Remembering familiar people: the posterior cingulate cortex and autobiographical memory retrieval. Neuroscience 104(3):667-76, 2001. PMID: 11440800. WOBIB: 90.

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-5: 0.00509 Reginald B. J. Adams; Heather L. Gordon; Abigail A. Baird; Nalini Ambady; Robert E. Kleck. Effects of gaze on amygdala sensitivity to anger and fear faces. Science 300(5625):1536, 2003. PMID: 12791983. DOI: 10.1126/science.1082244. WOBIB: 86.

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