WOBIB: 155 - Abel, et al. (2003) Ketamine alters neural ...
 
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Kathryn M. Abel; Matthew P. G. Allin; Katarzyna Kucharska-Pietura; Anthony S. David; Chris Andrew; Steven C. R. Williams; Michael J. Brammer; Mary L. Phillips. Ketamine alters neural processing of facial emotion recognition in healthy men: an fMRI study. NeuroReport 14(3):387-391, 2003. PMID: 12634489. DOI: 10.1097/01.wnr.0000058031.29600.31. FMRIDCID: . WOBIB: 155.

Disruption of facial emotion perception occurs in neuropsychiatric disorders where the expression of emotion is dulled or blunted, for example depersonalization disorder and schizophrenia. It has been suggested that, in the clinical context of emotional blunting, there is a shift in the relative contribution of brain regions subserving cognitive and emotional processing. The non-competitive glutamate receptor antagonist ketamine produces such emotional blunting in healthy subjects. Therefore, we hypothesised that in healthy subjects ketamine would elicit neural responses to emotional stimuli which mimicked those reported in depersonalization disorder and schizophrenia. Thus, we predicted that ketamine would produce reduced activity in limbic and visual brain regions involved in emotion processing, and increased activity in dorsal regions of the prefrontal cortex and cingulate gyrus, both associated with cognitive processing and, putatively, with emotion regulation. Measuring BOLD signal change in fMRI, we examined the neural correlates of ketamine-induced emotional blunting in eight young right-handed healthy men receiving an infusion of ketamine or saline placebo while viewing alternating 30 s blocks of faces displaying fear versus neutral expressions. The normal pattern of neural response occurred in limbic and visual cortex to fearful faces during the placebo infusion. Ketamine abolished this: significant BOLD signal change was demonstrated only in left visual cortex. However, with ketamine, neural responses were demonstrated to neutral expressions in visual cortex, cerebellum and left posterior cingulate gyrus. Emotional blunting may be associated with reduced limbic responses to emotional stimuli and a relative increase in the visual cortical response to neutral stimuli.

Asymmetry: -0.61669 (left: -1, right: +1)

VRML2 file (107 Kb)

1 Fearful face recognition with placebo drug. Fearful face recognition after placebo infusion versus neutral face recognition after placebo infusion. WOEXP: 475.
2 Neutral face recognition versus fearful with placebo drug. Neutral face recognition after placebo infusion versus fearful face recognition after placebo infusion. WOEXP: 476.
3 Fearful face recognition with ketamine drug. Fearful face recognition after ketamine-induced emotional blunting versus neutral face recognition after ketamine infusion. WOEXP: 477.
4 Neutral face recognition versus fearful with ketamine drug. Neutral face recognition after ketamine-induced emotional blunting versus fearful face recognition after ketamine infusion. WOEXP: 478.
5 Fearful face recognition with placebo drug versus with ketamine. Fearful face recognition after placebo infusion versus neutral face recognition after placebo infusion and fearful face recognition with ketamine. WOEXP: 479.
6 Neutral face recognition with ketamine versus fearful with placebo drug. Neutral face recognition after ketamine-induced emotional blunting versus with placebo infusion and fearful face recognition after ketamine infusion. WOEXP: 480.


corner cube of WOBIB_155

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