WOBIB: 140 - Zeki, et al. (1991) A direct demonstration ...
 
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Semir Zeki; J. D. Watson; C. J. Lueck; Karl J. Friston; C. Kennard; Richard S. J. Frackowiak. A direct demonstration of functional specialization in human visual cortex. Journal of Neuroscience 11(3):641-649, 1991. PMID: 2002358. FMRIDCID: . WOBIB: 140.

We have used positron emission tomography (PET), which measures regional cerebral blood flow (rCBF), to demonstrate directly the specialization of function in the normal human visual cortex. A novel technique, statistical parametric mapping, was used to detect foci of significant change in cerebral blood flow within the prestriate cortex, in order to localize those parts involved in the perception of color and visual motion. For color, we stimulated the subjects with a multicolored abstract display containing no recognizable objects (Land color Mondrian) and contrasted the resulting blood flow maps with those obtained when subjects viewed an identical display consisting of equiluminous shades of gray. The comparison identified a unique area (area V4) located in the lingual and fusiform gyri of the prestriate cortex. For motion, blood flow maps when subjects viewed moving or stationary black and white random-square patterns were contrasted. The comparison identified a unique area located in the region of the temporo-parieto-occipital junction (area V5). We thus provide direct evidence to show that, just as in the macaque monkey, different areas of the human prestriate visual cortex are specialized for different attributes of vision. The striate cortex (V1) and the contiguous visual area (V2), which in the monkey brain feed both the homologous areas, were active in all 4 conditions. This pattern of activity allowed us to use an extension of the approach to assess the functional relationship between the 3 areas during color and motion stimulation. This is based on an hypothesis-led analysis of the covariance structure of the blood flow maps and promises to be a powerful tool for inferring anatomical pathways in the normal human brain. In this study, we were able to demonstrate a positive functional relationship between areas V1/V2 and V4 during color vision and areas V1/V2 and V5 during motion stimulation, reflecting the anatomical connections between these areas in the macaque monkey.

Asymmetry: -0.31250 (left: -1, right: +1)

VRML2 file (62 Kb)

1 Vision. Vision by viewing a Mondrian-like images with a collage of colored or gray squares and rectangles of different shapes versus eyes closed. WOEXP: 428.
2 Color vision. Color vision by viewing a Mondrian-like with a collage of colored squares and rectangles of different shapes and colors versus colorless Mondrian image with isoluminant gray values. WOEXP: 429.
3 Visual motion. Visual motion by viewing 100 small moving black squares versus stationary dots. WOEXP: 430.


corner cube of WOBIB_140

Related - positive correlated volumes

+1: 1.00000 Semir Zeki; J. D. Watson; C. J. Lueck; Karl J. Friston; C. Kennard; Richard S. J. Frackowiak. A direct demonstration of functional specialization in human visual cortex. Journal of Neuroscience 11(3):641-649, 1991. PMID: 2002358. FMRIDCID: . WOBIB: 140.

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-3: 0.00000 Christian Gerlach; I. Law; Anders Gade; O. B. Paulson. The role of action knowledge in the comprehension of artefacts--a PET study. NeuroImage 15(1):143-52, 2002. PMID: 11771982. DOI: 10.1006/nimg.2002.0969. WOBIB: 34.

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-5: 0.00000 F. Hyder; E. A. Phelps; C. J. Wiggins; K. S. Labar; A. M. Blamire; R. G. Shulman. "Willed action": a functional MRI study of the human prefrontal cortex during a sensorimotor task. Proc Natl Acad Sci U S A 94(13):6989-6994, 1997. PMID: 9192679. WOBIB: 6.

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