WOBIB: 125 - Hansen, et al. (2002) The caudate nucleus i ...
 
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Elsebet S. Hansen; Steen Hasselbalch; Ian Law; Tom G. Bolwig. The caudate nucleus in obsessive-compulsive disorder. Reduced metabolism following treatment with paroxetine: a PET study. International Journal of Neuropsychopharmacology 5(1):1-10, 2002. PMID: 12057027. DOI: doi:10.1017/S1461145701002681. WOBIB: 125.

Several neuroimaging studies of patients with OCD have pointed to basal ganglia and the frontal cortical regions being relevant for an understanding of the pathophysiology and therapy of OCD. In a search for the neural substrate underlying the therapeutic action of paroxetine in the therapy of OCD we measured regional glucose metabolism in a PET study of 20 OCD patients before and after at least 3 months of treatment. We used 18-fluoro-deoxyglucose PET-scanning to measure regional cerebral glucose metabolic rate (rCMRglc) in 20 non-depressed patients fulfilling DSM-IV criteria for OCD. Patients were studied before and after 12-20 wk of treatment with the serotonin re-uptake inhibitor paroxetine. Clinical assessment rating with the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) was performed before the first and after the second study. The PET data was analysed regionally using statistical parametric mapping (SPM-96). A clinical improvement was indicated by a mean decrease of 55% in the Y-BOCS score. There was no difference in global cerebral metabolism before and after treatment whereas a post-treatment reduction in normalized rCMRglc was found in the right caudate nucleus. This finding also showed a significant positive correlation with symptom severity. Our results support hypotheses regarding a malfunction of the cortico-striato-thalamic system in the pathophysiology of OCD and particularly point to the caudate nucleus playing an important role for the therapeutic action of paroxetine in the treatment of OCD.

Asymmetry: 0.39276 (left: -1, right: +1)

VRML2 file (82 Kb)

1 Decrease in obsessive-compulsive disorder patients after treatment with paroxetine. Decrease in obsessive-compulsive disorder patients after treatment with paroxetine. WOEXP: 387.
2 Obsessive-compulsive disorder severity. Correlation with obsessive-compulsive disorder severity in patients before and after treatment with paroxetine. WOEXP: 388.


corner cube of WOBIB_125

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