WOBIB: 112 - Reiman, et al. (1996) Preclinical evidence ...
 
Bib -> Asymmetry | Author | ICA | NMF | Novelty | Statistics | SVD | Title | WOBIB ]
 
 
Exp -> Alphabetic | Asymmetry | ICA | NMF | Novelty | SVD | WOEXP | WOEXT ]
 
 
Ext -> Alphabetic index | Map | Roots ]          [ Brede ]          Loc -> Statistics ]
 


Eric M. Reiman; R. J. Caselli; L. S. Yun; K. Chen; D. Bandy; S. Minoshima; S. N. Thibodeau; D. Osborne. Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. New England Journal of Medicine 334(12):752-8, 1996. PMID: 8592548. WOBIB: 112.

BACKGROUND. Variants of the apolipoprotein E allele appear to account for most cases of late-onset Alzheimer's disease, and persons with two copies of the epsilon 4 allele appear to have an especially high risk of dementia. Positron-emission tomography (PET) has identified specific regions of the brain in which the rate of glucose metabolism declines progressively in patients with probable Alzheimer's disease. We used PET to investigate whether these same regions of the brain are affected in subjects homozygous for the epsilon 4 allele before the onset of cognitive impairment. METHODS. Apolipoprotein E genotypes were established in 235 volunteers 50 to 65 years of age who reported a family history of probable Alzheimer's disease. Neurologic and psychiatric evaluations, a battery of neuropsychological tests, magnetic resonance imaging, and PET were performed in 11 epsilon 4 homozygotes and 22 controls without the epsilon 4 allele who were matched for sex, age, and level of education. An automated method was used to generate an aggregate surface-projection map that compared regional rates of glucose metabolism in the two groups. RESULTS. The epsilon 4 homozygotes were cognitively normal. They had significantly reduced rates of glucose metabolism in the same posterior cingulate, parietal, temporal, and prefrontal regions as in previously studied patients with probable Alzheimer's disease. They also had reduced rates of glucose metabolism in additional prefrontal regions, which may be preferentially affected during normal aging. CONCLUSIONS. In late middle age, cognitively normal subjects who are homozygous for the epsilon 4 allele for apolipoprotein E have reduced glucose metabolism in the same regions of the brain as in patients with probable Alzheimer's disease. These findings provide preclinical evidence that the presence of the epsilon 4 allele is a risk factor for Alzheimer's disease. PET may offer a relatively rapid way of testing future treatments to prevent Alzheimer's disease.

Asymmetry: 0.00000 (left: -1, right: +1)

VRML2 file (65 Kb)

1 Apolipoprotein E e4 allele. CBF in healthy people with apolipoprotein E e4/e4 allele genotype versus controls with e2/e3 or e3/e3 genotype. WOEXP: 344.


corner cube of WOBIB_112

Related - positive correlated volumes

+1: 1.00000 Eric M. Reiman; R. J. Caselli; L. S. Yun; K. Chen; D. Bandy; S. Minoshima; S. N. Thibodeau; D. Osborne. Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. New England Journal of Medicine 334(12):752-8, 1996. PMID: 8592548. WOBIB: 112.

+2: 0.40920 Tatia M. C. Lee; Ho-Ling Liu; Li-Hai Tan; Chetwyn C. H. Chan; Srikanth Mahankali; Ching-Mei Feng; Jinwen Hou; Peter T. Fox; Jia-Hong Gao. Lie detection by functional magnetic resonance imaging. Human Brain Mapping 15(3):157-64, 2002. PMID: 11835606. WOBIB: 37.

+3: 0.36739 P. Pinel; S. Dehaene; D. Riviere; D. LeBihan. Modulation of parietal activation by semantic distance in a number comparison task. NeuroImage 14(5):1013-26, 2001. PMID: 11697933. DOI: 10.1006/nimg.2001.0913. WOBIB: 10.

+4: 0.35204 Gene E. Alexander; Kewei Chen; Pietro Pietrini; Stanley I. Rapoport; Eric M. Reiman. Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer's Disease Treatment Studies. American Journal of Psychiatry 159(5):738-45, 2002. PMID: 11986126. WOBIB: 91.

+5: 0.31986 Gordon L. Shulman; Julie A. Fiez; Maurizio Corbetta; Randy L. Buckner; Francis M. Miezin; Marcus E. Raichle; Steven E. Petersen. Common Blood Flow Changes across Visual Tasks: II. Decreases in Cerebral Cortex. Journal of Cognitive Neuroscience 9(5):648-663, 1997. FMRIDCID: . WOBIB: 173.

+6: 0.30398 Andreas Bartels; Semir Zeki. The neural basis of romantic love. NeuroReport 11(17):3829-3834, 2000. PMID: 11117499. WOBIB: 54.

+7: 0.29653 L. R. Becerra; H. C. Breiter; M. Stojanovic; S. Fishman; A. Edwards; A. R. Comite; R. G. Gonzalez; D. Borsook. Human brain activation under controlled thermal stimulation and habituation to noxious heat: an fMRI study. Magnetic Resonance in Medicine 41(5):1044-57, 1999. PMID: 10332889. WOBIB: 72.

+8: 0.29623 S. Aalto; P. Naatanen; E. Wallius; L. Metsahonkala; H. Stenman; P. M. Niem; H. Karlsson. Neuroanatomical substrata of amusement and sadness: a PET activation study using film stimuli. NeuroReport 13(1):67-73, 2002. PMID: 11924897. WOBIB: 88.

+9: 0.27956 S. J. Blakemore; Geraint Rees; C. D. Frith. How do we predict the consequences of our actions? A functional imaging study. Neuropsychologia 36(6):521-9, 1998. PMID: 9705062. WOBIB: 82.

+10: 0.27721 B. J. Casey; Jonathan D. Cohen; K. O'Craven; Richard J. Davidson; W. Irwin; C. A. Nelson; D. C. Noll; X. Hu; M. J. Lowe; B. R. Rosen; C. L. Truwitt; P. A. Turski. Reproducibility of fMRI results across four institutions using a spatial working memory task. NeuroImage 8(3):249-261, 1998. PMID: 9758739. FMRIDCID: . WOBIB: 116.

+11: 0.27475 Takashi Tsukiura; Toshikatsu Fujii; Reiko Fukatsu; Taisuke Otsuki; Jiro Okuda; Atsushi Umetsu; Kyoko Suzuki; Michio Tabuchi; Isao Yanagawa; Tatsuo Nagasaka; Ryuta Kawashima; Hiroshi Fukuda; Shoki Takahashi; Atsushi Yamadori. Neural basis of the retrieval of people's names: evidence from brain-damaged patients and fMRI. Journal of Cognitive Neuroscience 14(6):922-37, 2002. PMID: 12191459. DOI: 10.1162/089892902760191144. FMRIDCID: 2-2002-112QC. WOBIB: 41.

+12: 0.26775 K. Hugdahl; Ian Law; S. Kyllingsbaek; K. Bronnick; Anders Gade; Olaf B. Paulson. Effects of attention on dichotic listening: an 15O-PET study. Human Brain Mapping 10(2):87-97, 2000. PMID: 10864233. WOBIB: 14.

+13: 0.26652 M. M. Mesulam; A. C. Nobre; Y. H. Kim; T. B. Parrish; D. R. Gitelman. Heterogeneity of cingulate contributions to spatial attention. NeuroImage 13(6 Pt 1):1065-72, 2001. PMID: 11352612. DOI: 10.1006/nimg.2001.0768. WOBIB: 120.

+14: 0.25570 L. Ryan; L. Nadel; K. Keil; K. Putnam; D. Schnyer; T. Trouard; M. Moscovitch. Hippocampal complex and retrieval of recent and very remote autobiographical memories: evidence from functional magnetic resonance imaging in neurologically intact people. Hippocampus 11(6):707-14, 2001. PMID: 11811665. WOBIB: 73.

+15: 0.25386 Jean Decety; J. Grezes; N. Costes; Daniela Perani; Marc Jeannerod; E. Procyk; F. Grassi; F. Fazio. Brain activity during observation of actions. Influence of action content and subject's strategy. Brain 120 ( Pt 10):1763-77, 1997. PMID: 9365369. WOBIB: 49.

+16: 0.25364 Brent A. Vogt; Stuart Derbyshire; Anthony K. Jones. Pain processing in four regions of human cingulate cortex localized with co-registered PET and MR imaging. European Journal of Neuroscience 8(7):1461-73, 1996. PMID: 8758953. WOBIB: 100.

+17: 0.25057 Katharina Henke; Christian R. A. Mondadori; Valerie Treyer; Roger M. Nitsch; Alfred Buck; Christoph Hock. Nonconscious formation and reactivation of semantic associations by way of the medial temporal lobe. Neuropsychologia 41(8):863-876, 2003. PMID: 12667523. FMRIDCID: . WOBIB: 152.

+18: 0.25008 G. R. Fink; H. J. Markowitsch; M. Reinkemeier; T. Bruckbauer; J. Kessler; W. D. Heiss. Cerebral representation of one's own past: neural networks involved in autobiographical memory. Journal of Neuroscience 16(13):4275-82, 1996. PMID: 8753888. WOBIB: 68.

+19: 0.24531 F. Hyder; E. A. Phelps; C. J. Wiggins; K. S. Labar; A. M. Blamire; R. G. Shulman. "Willed action": a functional MRI study of the human prefrontal cortex during a sensorimotor task. Proc Natl Acad Sci U S A 94(13):6989-6994, 1997. PMID: 9192679. WOBIB: 6.

+20: 0.23252 Dottie M. Clower; John M. Hoffman; John R. Votaw; Tracy L. Faber; Roger P. Woods; Garrett E. Alexander. Role of posterior parietal cortex in the recalibration of visually guided reaching. Nature 383(6601):618-21, 1996. PMID: 8857536. WOBIB: 109.

+21: 0.23190 H. Okazawa; M. Leyton; C. Benkelfat; S. Mzengeza; M. Diksic. Statistical mapping analysis of serotonin synthesis images generated in healthy volunteers using positron-emission tomography and alpha-[11C]methyl-L-tryptophan. Journal of Psychiatry Neuroscience 25(4):359-370, 2000. PMID: 11022401. WOBIB: 89.

+22: 0.23139 Christian Gerlach; I. Law; Anders Gade; O. B. Paulson. Categorization and category effects in normal object recognition: a PET study. Neuropsychologia 38(13):1693-703, 2000. PMID: 11099727. WOBIB: 2.

+23: 0.22834 Greig I. de Zubicaray; Katie McMahon; Stephen J. Wilson; Santhi Muthiah. Brain activity during the encoding, retention, and retrieval of stimulus representations. Learning & Memory 8(5):243-251, 2001. PMID: 11584070. DOI: 10.1101/lm.40301. FMRIDCID: . WOBIB: 141.

+24: 0.22656 Richard J. Maddock; Amy S. Garrett; Michael H. Buonocore. Posterior cingulate cortex activation by emotional words: fMRI evidence from a valence decision task. Human Brain Mapping 18(1):30-41, 2003. PMID: 12454910. DOI: 10.1002/hbm.10075. WOBIB: 39.

+25: 0.22641 P. Belin; Robert J. Zatorre; P. Lafaille; P. Ahad; B. Pike. Voice-selective areas in human auditory cortex. Nature 403(6767):309-312, 2000. PMID: 10659849. DOI: 10.1038/35002078. WOBIB: 42.


Antirelated - negatively correlated volumes

-1: 0.00037 Reginald B. J. Adams; Heather L. Gordon; Abigail A. Baird; Nalini Ambady; Robert E. Kleck. Effects of gaze on amygdala sensitivity to anger and fear faces. Science 300(5625):1536, 2003. PMID: 12791983. DOI: 10.1126/science.1082244. WOBIB: 86.

-2: 0.00077 Noam Sobel; V. Prabhakaran; John E. Desmond; Gary H. Glover; R. L. Goode; Edith V. Sullivan; John D. E. Gabrieli. Sniffing and smelling: separate subsystems in the human olfactory cortex. Nature 392(6673):282-286, 1998. PMID: 9521322. DOI: 10.1038/32654. FMRIDCID: . WOBIB: 162.

-3: 0.00090 J. D. Bremner; R. B. Innis; S. M. Southwick; L. Staib; S. Zoghbi; D. S. Charney. Decreased benzodiazepine receptor binding in prefrontal cortex in combat-related posttraumatic stress disorder. American Journal of Psychiatry 157(7):1120-1126, 2000. PMID: 10873921. WOBIB: 67.

-4: 0.00108 Helen L. Gallagher; Anthony I. Jack; Andreas Roepstorff; Christopher D. Frith. Imaging the intentional stance in a competitive game. NeuroImage 16(3 Pt 1):814-21, 2002. PMID: 12169265. WOBIB: 70.

-5: 0.00209 Semir Zeki; J. D. Watson; C. J. Lueck; Karl J. Friston; C. Kennard; Richard S. J. Frackowiak. A direct demonstration of functional specialization in human visual cortex. Journal of Neuroscience 11(3):641-649, 1991. PMID: 2002358. FMRIDCID: . WOBIB: 140.

Bib -> Asymmetry | Author | ICA | NMF | Novelty | Statistics | SVD | Title | WOBIB ]
Exp -> Alphabetic | Asymmetry | ICA | NMF | Novelty | SVD | WOEXP | WOEXT ]
Ext -> Alphabetic index | Map | Roots ]          [ Brede ]          Loc -> Statistics ]
Automatically constructed by Brede Toolbox through brede_bib_bib2html, 2006-08-15T20:33:55